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Image Search Results
Journal: Frontiers in Pharmacology
Article Title: β 3 Adrenergic Receptor Stimulation Promotes Reperfusion in Ischemic Limbs in a Murine Diabetic Model
doi: 10.3389/fphar.2021.666334
Figure Lengend Snippet: β 3 AR-stimulated angiogenesis is NOS-dependent. (A) Tubule formation in HUVECs and the effect of l -NAME (300 μmol/L); n = 5 (B) cell migration rate in HUVECs and the effect of l -NAME (300 μmol/L); n = 4. (C) Tubule formation in human adult dermal microvascular endothelial cells (MVEC) and (D) patient-derived endothelial colony forming cells (ECFC) with β 3 AR agonist CL 316,243 (100 ng/ml) and β 3 AR antagonist, SR 592630 A (1 μmol/L) n = 3. (E) Representative images in ECFCs and (F) participant characteristics and medical history of ECFC source. Mean ± SEM; ** p < 0.01, **** p < 0.0001 vs control; # p < 0.05, ## p < 0.01, #### p < 0.0001 vs. CL 316,243 by 1-way ANOVA with Bonferroni post-hoc analysis or 2-way ANOVA. ACE/ARB, angiotensin converting enzyme inhibitor/angiotensin receptor blocker; BMI, body mass index; CACS, coronary artery calcium score; SPS, soft plaque score.
Article Snippet:
Techniques: Migration, Derivative Assay, Control